"The ideal mouse will impose a lesser degree of musculoskeletal stress on the fingers and hand. Essentially, it will keep the hand and fingers in the neutral position for longer periods of time. This is one of the great benefits of the Quadra Clicks RBT mouse. It reduces tendon stress and simultaneously provides less muscle fatigue for increased accuracy and performance as compared to conventional computer mouse devices. Most importantly, it will greatly reduce the probability of acquiring a tendon pathology like carpal tunnel syndrome. By extension, therefore, we can classify the Quadra Clicks RBT mouse as a “preventative measure” against carpal tunnel syndrome." -Dr. Z  (Maik Zannakis) Neurophysiologist, Bioengineer, and Medical Director @CarpalRX

"While this innovation (RBT) might seem minor at first, when looking at the mechanics of clicking from the anatomical lens, this small shift actually makes lasting impact on the overall health of your hand by decreasing the amount of stress on the flexor tendons of your digits. By lessening the overexertion of your tendons, this mouse can work to actively fight against tendinopathies as well as other repetitive motion injuries of your hand. I personally use the RBT mouse for its comfort and innovative design knowing that it can promote the longevity of my hands."- Bryan Kang OTD,  OTR/L Occupational Therapist / Hand Therapist @Kaiser Permanente

"I'm a project manager/senior designer and spend 90% of my time on ArchiCAD.  A few years ago I was working on my own house remodel and was drafting 80+ hours a week, which led to tendonitis.  This happens to me pretty regularly when I'm trying to meet a deadline, and for years I've tried different mice and desk setups to no avail.  I found the RBT mouse at a convention and did not hesitate to try it out, especially since it was a fraction of the cost of my expensive gaming mouse.  The responsiveness is superb and the side buttons are a must for CAD.  Within a week I was able to retrain the way my fingers clicked and I have not had any pain since.  I am extremely happy with the mouse and purchased a second one for gaming on my home computer.  I would recommend this mouse to anyone who spends a lot of time doing repetitive mouse clicking.
The left mouse click does the typical selections, and the right mouse click will open settings for the selected item.  I use the scroll wheel to zoom in and out, and I can pan by pressing down on the scroll wheel.  For the side buttons I customized keystrokes so I can use them to go up and down stories when I'm modeling a house.  ArchiCAD is a BIM software so drafting and modeling go hand in hand.  Having all the buttons makes navigating the floor plans and 3D model really simple." - Meching M. Lau Morgan Smith Architect

"QuadraClicks are out to save the world one hand at a time, and I’m glad the mouse made its way into my own hand. And I didn’t even know it needed saving."  - FirstLook

"The unconstrained grip feels natural, and it's being endorsed by blender team" - BlenderNation

"RBT Helps Reduce Headache and numbness in fingers" - OverClockers 

"Eliminates Risk of Trigger Finger, Reduces Pain and Force of Clicking, Click Cleanly With No Unintended Mouse Movement, Can Reduce Fingertip Sensitivity, Minimal Learning Curve, Can Reduce Wrist Extension, and Provides 'Gap' Under Hand"- ErgoCanada 

"Easy on the thumb, Keeps De Quervain’s Tenosynovitis at bay!" - HardwareHound

Carpal tunnel syndrome results in the highest number of days lost among all work related injuries. Almost half of the carpal tunnel cases result in 31 days or more of work loss.National Center for Health Statistics

Carpal Tunnel Injuries affected over 5 million U.S. workers in 2010 and are growing.  PubMed

CTS surgery occurs between 400,000 and 500,000 cases annually in the US with an economic cost of over $2 billion. PubMed